![a negative blood type and von willebrand a negative blood type and von willebrand](https://onlinelibrary.wiley.com/cms/asset/ee1ccddb-4a4f-4648-8049-812fef234cb9/bjh16681-fig-0003-m.jpg)
Age has to be considered a minor modification factor, as there is a consistent, but weak, increase in FVIII levels with age,” they wrote.
![a negative blood type and von willebrand a negative blood type and von willebrand](https://onlinelibrary.wiley.com/cms/asset/260a918f-f815-4e83-b8ce-fad3a36211de/jth13294-fig-0003-m.jpg)
“We conclude that for the assessment of FVIII levels in patients with mild or moderate haemophilia A neither the ABO, nor the VWF level, have to be taken into account. Share this article Share with email Share with twitter Share with linkedin Share with facebook.
#A NEGATIVE BLOOD TYPE AND VON WILLEBRAND DRIVERS#
These findings indicate that although factors such as age may influence FVIII levels in non-severe hemophilia A, genetic mutations are likely the main drivers mediating this protein’s levels, the scientists said. Cell type-specific regulation of von Willebrand factor expression by the E4BP4 transcriptional repressor. Conclusions: Aging and ABO blood type have an interrelated effect on VWF and FVIII levels, where the effect of one is signicantly inuenced by the presence of the other. However, in healthy individuals, the combination of blood group, VWF levels, and age explained 61.3% of the variation in FVIII activity. blood type on VWF secretion with aging, as old individu-als with blood type non-O showed higher levels of VWFpp (mean difference 0.29 U/mL). A similar association was also found between patients’ age and VWF levels and activity.įurther analysis showed that neither blood group, VWF levels, nor age were significantly associated with FVIII activity in patients. The association between age and FVIII activity was not significant, but there was a weak correlation between older age and higher FVIII levels.
![a negative blood type and von willebrand a negative blood type and von willebrand](https://ars.els-cdn.com/content/image/1-s2.0-S0022283619300919-ga1.jpg)
Next, they analyzed the influence of age on FVIII and VWF levels in hemophilia patients. In fact, the team estimated that a 1% increase in VWF levels or activity correlated with a 0.73–0.77% increase in FVIII activity. Healthy individuals from the non-O groups also had higher levels of VWF (126%) than those in the O group (86%). The activity of VWF was also higher in the non-O group than in the O group - 117% versus 71%. In controls, those with a non-O blood type had higher levels of FVIII than those in the O group - 150% versus 109.5%. Neither was a correlation found between FVIII activity and VWF activity or levels in patients. Results showed no significant differences in FVIII activity across the blood type groups in hemophilia A patients. Eighty-five patients showed 46 different mutations in the F8 gene. In the control group, 32 participants (39%) belonged to the O blood group and 50 (61%) had a different blood type. In the hemophilia A group, 47 patients (52.8%) belonged to the O blood group, and 42 (47.2%) to non-O groups.